3-088 Research Transition Facility
My work has focussed mainly on neural substrates of behaviour with a focus on animal models of reward and of psychotherapeutic drug action. Recent studies have revealed novel interactions of specific chemical messengers (including the amino acids glutamate and GABA, and two amines: dopamine and serotonin). The results of such experiments are relevant to gaining a clearer understanding of brain function and to the development of more effective treatments for the psychiatric disorders of depression, schizophrenia and substance abuse. My current research interests, in motivation and reward have moved into the domain of functional brain imaging (fMRI) with human subjects – the focal points of this research are twofold:
- With the CARPI group – neurodevelopmental, targeting differences between “behaviourally high risk” and control populations of children and adolescents.
- With the TRANSALC group – studying aspects of mental health and addictions in adults. My general academic interests include a broad range of biological and psychosocial areas.
- Greenshaw AJ. Advancing Mental Health in the Arctic. Invited lecture to the Alberta Psychiatric Association Banff April 2011
- Brown M, Greenshaw AJ and Dursun S. MRI investigations of alcoholism and addiction. Invited presentation to European Winter Brain Conference Les Deux Alpes, France March 2011.
- Greenshaw AJ. Neurobiology of Reward Invited lecture to symposium on Recent Advances in Neuroscience , Shri Guru Ram Rai Institute of Medicine & Health Science Dehradun Uttar Pradesh India December 2010.
- Greenshaw AJ. 5-HT receptors in motivation and reward Invited lecture to Joint Federation of Asia-Oceanic Neuroscience Societies and the Indian Academy of Neurosciences, Lucknow Uttar Pradesh India November 2010.
- Hayes DJ, Greenshaw AJ. (2011) 5-HT receptors and reward-related behaviour: a review. Neurosci Biobehav Rev. 2011 35:1419-49.
- Hayes DJ, Hoang J and Greenshaw AJ. (2010) The role of nucleus accumbens shell GABA receptors on ventral tegmental area intracranial self-stimulation and a potential role for the 5-HT2C receptor. J. Psychopharmacology Dec 17 [Epub ahead of print]
- Hayes DJ, Clements R, Greenshaw AJ. (2009) Effects of systemic and intra-nucleus accumbens 5-HT(2C) receptor compounds on ventral tegmental area self-stimulation thresholds in rats Psychopharmacology 203:579–588
- Hayes D.J. Mosher T.M. and Greenshaw A.J. (2009) Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats Behavioural Brain Research 11;197(2):323-30.
- Hayes D.J. Graham D.A. and Greenshaw AJ (2009) Effects of systemic 5-HT1B receptor compounds on ventral tegmental area intracranial self-stimulation thresholds in rats. European Journal of Pharmacology 14:74-78.
- McGrath BM, McKay R, Dave S, Seres P, Weljie AM, Slupsky CM, Hanstock CC,Greenshaw AJ, Silverstone PH. (2008) Acute Dextro-Amphetamine administration does not alter Brain myo-Inositol Levels in Humans and Animals: MRS Investigations at 3T and 18.8T. Neuroscience Research, 61:351-359.