Lonnie Zwaigenbaum

Adjunct Associate Professor

AHFMR Health Scholar, Co-director - Autism Research Centre, Associate Professor - Department of Pediatrics



My research focuses on early development in autism and related neurodevelopmental disorders. With the goals of identifying early behavioural and neurobiological markers of autism, my research group is following a high-risk cohort; namely, infant siblings of children with autism. This is helping us identify specific risk markers to aid in earlier diagnosis and study basic processes (e.g., attention, emotion, executive control) that may underlie later symptoms. My colleagues and I are also embarking on a longitudinal MRI study of these high-risk infants to help determine the relationship between abnormalities in brain growth and connectivity, and the onset and progression of behavioural manifestations of autism. Other research includes genetic studies of autism using molecular and genomic strategies, a national longitudinal study of developmental trajectories and outcomes in newly diagnosed preschool children with autism, and a qualitative study of the values, priorities and worldviews of families of children with autism. Other areas of interest include screening/early diagnosis, intervention studies, and epidemiology of autism.‚Äč

Publications

  • Zwaigenbaum L, Bryson S, Roberts W, Rogers T, Brian J, & Szatmari P. (2005). Behavioral markers of autism in the first year of life. International Journal of Developmental Neurosciences; 23,143-52 
  • DiCicco-Bloom E, Lord C, Zwaigenbaum L, Courchesne E, Dager S, Schmitz C, Schultz R, Crawley J, & Young L. (2006). Developmental Neurobiology of Autism Spectrum Disorders: Clinical Phenotypes, Neurobiologic Abnormalities and Animal Models. Journal of Neuroscience, 26, 6897-6906. 
  • Zwaigenbaum L, Thurm A, Stone W, Baranek G, Bryson SE, Iverson J, Kau A, Klin A, Lord C, Landa R, Rogers S, & Sigman M. (2007). Studying the emergence of autism spectrum disorders in high risk infants: Methodological and practical issues, Journal of Autism and Developmental Disorders, 37, 466-480. 
  • Bryson SE, Zwaigenbaum L, Brian J, Roberts W, Szatmari P, McDermott C (2007). A prospective case series of high-risk infants who developed autism. Journal of Autism and Developmental Disabilities, 37, 12-24. 
  • Georgiades S, Szatmari P, Bryson SE, Zwaigenbaum L, Goldberg J, Mahoney W, Roberts W, & Duku E. (2007). The structure of the autism symptom phenotype: A proposed multidimensional model. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 188-96. 
  • The Autism Genome Project Consortium; Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, et al. (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics, 39, 318-329. 
  • Szatmari P, Maziade M, Zwaigenbaum L, Merette C, Roy M-A, Palmour R, & Joober R. (2007). Informative Phenotypes for Genetic Studies of Psychiatric Disorders. Neuropsychiatric Genetics. [Epub; PMID: 17219386]. 
  • Mosconi M, Zwaigenbaum L, & Piven J. (in press). Structural MRI in autism: Findings and future directions. Clinical Neurosciences Research.